Local pH domains regulate NHE 3 mediated Na + reabsorption in the renal 1 proximal tubule 2 Jens
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چکیده
Jens Christian Brasen, James L. Burford, Alicia A. McDonough, Niels-Henrik Holstein3 Rathlou, Janos Peti-Peterdi 4 5 Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 6 Copenhagen N, Denmark. 7 Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, 8 DK-2800 Lyngby, Denmark 9 Departments of Physiology and Biophysics, and Zilkha Neurogenetic Institute, and Cell and 10 Neurobiology, University of Southern California, Los Angeles, CA 90033, USA 11 12 * Corresponding author 13 Jens Christian Brasen 14 [email protected]; [email protected] 15 16 17 18 Articles in PresS. Am J Physiol Renal Physiol (October 8, 2014). doi:10.1152/ajprenal.00174.2014
منابع مشابه
Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.
The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule. In response to a rise in blood pressure NHE3 redistributes in the plane of the plasma membrane to the base of the brush border, where NHE3 activity is reduced. This NHE3 redistribution is assumed to provo...
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تاریخ انتشار 2014